Journal of Archives in Military Medicine

Published by: Kowsar

Alopecia Areata: The Role of Stressful Events and an Estimate of Lifetime Risk in First-Degree Relatives

Alireza Khoshdel 1 , * , Arash Shekari 2 , 3 , Koosha Paydary 3 and Iraj Shekari 3
Authors Information
1 Department of Epidemiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, IR Iran
2 Epidemiology Research Center, AJA University of Medical Sciences, Tehran, IR Iran
3 Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Journal of Archives in Military Medicine: February 01, 2016, 4 (1); e36377
  • Published Online: February 17, 2016
  • Article Type: Research Article
  • Received: January 16, 2016
  • Accepted: January 16, 2016
  • DOI: 10.5812/jamm.36377

To Cite: Khoshdel A, Shekari A, Paydary K, Shekari I. Alopecia Areata: The Role of Stressful Events and an Estimate of Lifetime Risk in First-Degree Relatives, J Arch Mil Med. 2016 ; 4(1):e36377. doi: 10.5812/jamm.36377.

Copyright © 2016, AJA University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Alexis AF, Dudda-Subramanya R, Sinha AA. Alopecia areata: autoimmune basis of hair loss. Eur J Dermatol. 2004; 14(6): 364-70[PubMed]
  • 2. McElwee KJ, Tobin DJ, Bystryn JC, King LJ, Sundberg JP. Alopecia areata: an autoimmune disease? Exp Dermatol. 1999; 8(5): 371-9[PubMed]
  • 3. Green J, Sinclair RD. Genetics of alopecia areata. Australas J Dermatol. 2000; 41(4): 213-8[PubMed]
  • 4. Anderson I. Alopecia areata: a clinical study. Br Med J. 1950; 2(4691): 1250-2[PubMed]
  • 5. Muller SA, Winkelmann RK. Alopecia Areata. An Evaluation of 736 Patients. Arch Dermatol. 1963; 88: 290-7[PubMed]
  • 6. Valsecchi R, Vicari O, Frigeni A, Foiadelli L, Naldi L, Cainelli T. Familial alopecia areata--genetic susceptibility or coincidence? Acta Derm Venereol. 1985; 65(2): 175-7[PubMed]
  • 7. Sharma VK, Kumar B, Surrinder K, Inderjeet K. Alopecia areata. A clinical study of 250 patients. Ind j dermatol venereol leprol. 1988; 54(3): 132-6
  • 8. Shellow WV, Edwards JE, Koo JY. Profile of alopecia areata: a questionnaire analysis of patient and family. Int J Dermatol. 1992; 31(3): 186-9[PubMed]
  • 9. van der Steen P, Traupe H, Happle R, Boezeman J, Strater R, Hamm H. The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol. 1992; 72(5): 373-5[PubMed]
  • 10. Ro BI. Alopecia areata in Korea (1982-1994). J Dermatol. 1995; 22(11): 858-64[PubMed]
  • 11. Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol. 1996; 35(1): 22-7[PubMed]
  • 12. Tan E, Tay YK, Goh CL, Chin Giam Y. The pattern and profile of alopecia areata in Singapore--a study of 219 Asians. Int J Dermatol. 2002; 41(11): 748-53[PubMed]
  • 13. Yang S, Yang J, Liu JB, Wang HY, Yang Q, Gao M, et al. The genetic epidemiology of alopecia areata in China. Br J Dermatol. 2004; 151(1): 16-23[DOI][PubMed]
  • 14. Blaumeiser B, van der Goot I, Fimmers R, Hanneken S, Ritzmann S, Seymons K, et al. Familial aggregation of alopecia areata. J Am Acad Dermatol. 2006; 54(4): 627-32[DOI][PubMed]
  • 15. Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol. 2006; 20(9): 1055-60[DOI][PubMed]
  • 16. Kavak A, Yesildal N, Parlak AH, Gokdemir G, Aydogan I, Anul H, et al. Alopecia areata in Turkey: demographic and clinical features. J Eur Acad Dermatol Venereol. 2008; 22(8): 977-81[DOI][PubMed]
  • 17. Al-Mutairi N, Eldin ON. Clinical profile and impact on quality of life: seven years experience with patients of alopecia areata. Indian J Dermatol Venereol Leprol. 2011; 77(4): 489-93[DOI][PubMed]
  • 18. Manolache L, Benea V. Stress in patients with alopecia areata and vitiligo. J Eur Acad Dermatol Venereol. 2007; 21(7): 921-8[DOI][PubMed]
  • 19. Wygledowska-Kania M, Bogdanowski T. [Psychic factors in case histories of patients with alopecia areata--preliminary report]. Psychiatr Pol. 1996; 30(4): 669-76[PubMed]
  • 20. Willemsen R, Vanderlinden J, Roseeuw D, Haentjens P. Increased history of childhood and lifetime traumatic events among adults with alopecia areata. J Am Acad Dermatol. 2009; 60(3): 388-93[DOI][PubMed]
  • 21. Diaz-Atienza F, Gurpegui M. Environmental stress but not subjective distress in children or adolescents with alopecia areata. J Psychosom Res. 2011; 71(2): 102-7[DOI][PubMed]
  • 22. Picardi A, Pasquini P, Cattaruzza MS, Gaetano P, Baliva G, Melchi CF, et al. Psychosomatic factors in first-onset alopecia areata. Psychosomatics. 2003; 44(5): 374-81[DOI][PubMed]
  • 23. Holmes TH, Rahe RH. The Social Readjustment Rating Scale. J Psychosom Res. 1967; 11(2): 213-8[PubMed]
  • 24. Nia ME, Aliloo MM, Ansarin K. The role of stress and coping strategies in the emergence of asthma, and the moderating effects of gender in this illness. Procedia - Social and Behavioral Sciences. 2010; 5: 910-4
  • 25. Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, et al. Alopecia areata investigational assessment guidelines--Part II. National Alopecia Areata Foundation. J Am Acad Dermatol. 2004; 51(3): 440-7[DOI][PubMed]
  • 26. Colombe BW, Price VH, Khoury EL, Garovoy MR, Lou CD. HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol. 1995; 33(5 Pt 1): 757-64[PubMed]
  • 27. Brajac I, Tkalcic M, Dragojevic DM, Gruber F. Roles of stress, stress perception and trait-anxiety in the onset and course of alopecia areata. J Dermatol. 2003; 30(12): 871-8[PubMed]
  • 28. Gulec AT, Tanriverdi N, Duru C, Saray Y, Akcali C. The role of psychological factors in alopecia areata and the impact of the disease on the quality of life. Int J Dermatol. 2004; 43(5): 352-6[DOI][PubMed]
  • 29. Gupta MA, Gupta AK, Watteel GN. Stress and alopecia areata: a psychodermatologic study. Acta Derm Venereol. 1997; 77(4): 296-8[PubMed]
  • 30. Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton L3. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995; 70(7): 628-33[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments