Journal of Archives in Military Medicine

Published by: Kowsar

Alteration of Lipid Peroxidation and Total Antioxidant Capacity in Patients With Head and Neck Cancers Following Radiotherapy

Soheila Manifar 1 , Farid Abbassi 2 , Iraj Mirzaii Dizgah 3 , Roya Khatami 2 , * , Mostafa Esmseil 2 and Afshin Almasi 4
Authors Information
1 Department of Oral and Dental Disease, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran
2 Department of Oral and Dental Disease, School of Dentistry, Shahed University, Tehran, IR Iran
3 Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, IR Iran
4 Clinical Research Development Center, Department of Biostatistics and Epidemiology, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
Article information
  • Journal of Archives in Military Medicine: November 01, 2015, 3 (4); e30431
  • Published Online: November 10, 2015
  • Article Type: Research Article
  • Received: June 4, 2015
  • Revised: July 14, 2015
  • Accepted: July 14, 2015
  • DOI: 10.5812/jamm.30431

To Cite: Manifar S, Abbassi F, Mirzaii Dizgah I, Khatami R, Esmseil M, et al. Alteration of Lipid Peroxidation and Total Antioxidant Capacity in Patients With Head and Neck Cancers Following Radiotherapy, J Arch Mil Med. 2015 ; 3(4):e30431. doi: 10.5812/jamm.30431.

Copyright © 2015, AJA University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Choong N, Vokes E. Expanding role of the medical oncologist in the management of head and neck cancer. CA Cancer J Clin. 2008; 58(1): 32-53[DOI][PubMed]
  • 2. Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: Differences by country, sex and anatomic site. Oral Oncol. 2014; 50(5): 387-403[DOI]
  • 3. Freedman ND, Abnet CC, Leitzmann MF, Hollenbeck AR, Schatzkin A. Prospective investigation of the cigarette smoking-head and neck cancer association by sex. Cancer. 2007; 110(7): 1593-601[DOI][PubMed]
  • 4. Patel BP, Rawal UM, Rawal RM, Shukla SN, Patel PS. Tobacco, Antioxidant Enzymes, Oxidative Stress, and Genetic Susceptibility in Oral Cancer. Am J Clin Oncol. 2008; 31(5): 454-9[DOI]
  • 5. Rasheed MH, Beevi SS, Geetha A. Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma. Oral Oncol. 2007; 43(4): 333-8[DOI][PubMed]
  • 6. Beevi SS, Rasheed AM, Geetha A. Evaluation of oxidative stress and nitric oxide levels in patients with oral cavity cancer. Jpn J Clin Oncol. 2004; 34(7): 379-85[DOI][PubMed]
  • 7. Lawrance JAL, Mais KL, Slevin NJ. Radiologically Inserted Gastrostomies: their use in Patients with Cancer of the Upper Aerodigestive Tract. Clin Oncol. 2003; 15(3): 87-91[DOI]
  • 8. Sakhi AK, Russnes KM, Thoresen M, Bastani NE, Karlsen A, Smeland S, et al. Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study. BMC Cancer. 2009; 9(1): 458[DOI]
  • 9. Koskinen W. Prognostic markers in head and neck carcinoma. 2006;
  • 10. Agha-Hosseini F, Mirzaii-Dizgah I, Mahboobi N, Shirazian S, Harirchi I. Serum and Saliva MMP-3 in Patients with OLP and Oral SCC. J Contemp Dent Pract. 2015; 16(2): 107-11[PubMed]
  • 11. Mominzadeh M, Mirzaii-Dizgah I, Mirzaii-Dizgah MR, Mirzaii-Dizgah MH. Stimulated Saliva Aminotransaminase Alteration After Experiencing Acute Hypoxia Training. Air Med J. 2014; 33(4): 157-60[DOI]
  • 12. Mirzaii-Dizgah I, Riahi E. Salivary troponin I as an indicator of myocardial infarction. Indian J Med Res. 2013; 138(6): 861-5[PubMed]
  • 13. Agha-Hosseini F, Mirzaii-Dizgah I, Mirjalili N. Unstimulated whole saliva 25-hydroxycholecalciferol in patients with xerostomia in menopausal women. Aging Clin Exp Res. 2013; 25(2): 147-51[DOI]
  • 14. Mirzaii-Dizgah I, Riahi E. Salivary high-sensitivity cardiac troponin T levels in patients with acute myocardial infarction. Oral Dis. 2013; 19(2): 180-4[DOI]
  • 15. Mirzaii-Dizgah I, Hejazi SF, Riahi E, Salehi MM. Saliva-based creatine kinase MB measurement as a potential point-of-care testing for detection of myocardial infarction. Clin Oral Investigat. 2011; 16(3): 775-9[DOI]
  • 16. Mirzaii-Dizgah I, Agha-Hosseini F. Unstimulated whole saliva parathyroid hormone in postmenopausal women with xerostomia. J Contemp Dent Pract. 2011; 12(3): 196-9[PubMed]
  • 17. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004; 37(4): 277-85[DOI][PubMed]
  • 18. Agha-Hosseini F, Mirzaii-Dizgah I, Farmanbar N, Abdollahi M. Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma. J Oral Pathol Med. 2012; 41(10): 736-40[DOI]
  • 19. Blair IA. DNA adducts with lipid peroxidation products. J Biol Chem. 2008; 283(23): 15545-9[DOI][PubMed]
  • 20. Halliwell B. Oxidative stress and cancer: have we moved forward? Biochem J. 2007; 401(1): 1-11[DOI][PubMed]
  • 21. Malathi M, Vijay M, Shivashankara AR. The role of oxidative stress and the effect of radiotherapy on the plasma oxidant-antioxidant status in head and neck cancer. J Clin Diagnos Res. 2011; 5(2): 249-51
  • 22. Kasapović J, Pejić S, Stojiljković V, Todorović A, Radošević-Jelić L, Saičić ZS, et al. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. Clin biochem. 2010; 43(16): 1287-93
  • 23. Sabitha KE, Shyamaladevi CS. Oxidant and antioxidant activity changes in patients with oral cancer and treated with radiotherapy. Oral Oncol. 1999; 35(3): 273-7[DOI]
  • 24. Chitra S, Shyamala Devi CS. Effect of alpha-tocopherol on pro-oxidant and antioxidant enzyme status in radiation-treated oral squamous cell carcinoma. Indian J Med Sci. 2008; 62(4): 141-8[PubMed]
  • 25. Gupta A, Bhatt ML, Misra MK. Assessment of free radical-mediated damage in head and neck squamous cell carcinoma patients and after treatment with radiotherapy. Indian J Biochem Biophys. 2010; 47(2): 96-9[PubMed]
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