Journal of Archives in Military Medicine

Published by: Kowsar

A Challenging in Diagnosis of Mucous Membrane Pemphigoid with Desquamative Gingivitis Presentation: A Case Report

Maryam Koopaie 1 , *
Author Information
1 Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Archives in Military Medicine: March 2018, 6 (1); e64548
  • Published Online: March 31, 2018
  • Article Type: Case Report
  • Received: November 28, 2017
  • Revised: March 12, 2018
  • Accepted: March 18, 2018
  • DOI: 10.5812/jamm.64548

To Cite: Koopaie M. A Challenging in Diagnosis of Mucous Membrane Pemphigoid with Desquamative Gingivitis Presentation: A Case Report, J Arch Mil Med. 2018 ; 6(1):e64548. doi: 10.5812/jamm.64548.

Copyright © 2018, Journal of Archives in Military Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Vijayan V, Paul A, Babu K, Madhan B. Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid. J Indian Soc Periodontol. 2016;20(3):340-3. doi: 10.4103/0972-124X.182602. [PubMed: 27563211].
  • 2. Al-Abeedi F, Aldahish Y, Almotawa Z, Kujan O. The Differential Diagnosis of Desquamative Gingivitis: Review of the Literature and Clinical Guide for Dental Undergraduates. J Int Oral Health. 2015;7(Suppl 1):88-92. doi: 10.4103/2278-9626.163338. [PubMed: 26225114].
  • 3. Glick M. Burket's Oral Medicine. 12 ed. USA: People's Medical Publishing House; 2015. p. 69-83.
  • 4. Hasan S. Desquamative gingivitis - A clinical sign in mucous membrane pemphigoid: Report of a case and review of literature. J Pharm Bioallied Sci. 2014;6(2):122-6. doi: 10.4103/0975-7406.129177. [PubMed: 24741281].
  • 5. Hasan S, Kapoor B, Siddiqui A, Srivastava H, Akhtar Y, Fatima S. Mucous membrane pemphigoid with exclusive gingival involvement: Report of a case and review of literature. J Orofac Sci. 2012;4(1):64-9. doi: 10.4103/0975-8844.99884.
  • 6. Arash A, Shirin L. The management of oral mucous membrane pemphigoid with dapsone and topical corticosteroid. J Oral Pathol Med. 2008;37(6):341-4. doi: 10.1111/j.1600-0714.2008.00653.x. [PubMed: 18331284].
  • 7. Suresh L, Neiders ME. Definitive and differential diagnosis of desquamative gingivitis through direct immunofluorescence studies. J Periodontol. 2012;83(10):1270-8. doi: 10.1902/jop.2012.110627. [PubMed: 22264207].
  • 8. Neff AG, Turner M, Mutasim DF. Treatment strategies in mucous membrane pemphigoid. Ther Clin Risk Manag. 2008;4(3):617-26. doi: 10.2147/TCRM.S1140. [PubMed: 18827857].
  • 9. Darling MR, Daley T. Blistering mucocutaneous diseases of the oral mucosa--a review: part 2. Pemphigus vulgaris. J Can Dent Assoc. 2006;72(1):63-6. [PubMed: 16480607].
  • 10. Robinson NA, Wray D. Desquamative gingivitis: a sign of mucocutaneous disorders--a review. Aust Dent J. 2003;48(4):206-11. [PubMed: 14738122].
  • 11. Saito A, Makiishi T. Chronic desquamative gingivitis and oral health-related quality of life. J Dermatol Case Rep. 2009;3(3):47-9. doi: 10.3315/jdcr.2009.1034. [PubMed: 21886731].
  • 12. Gagari E, Damoulis PD. Desquamative gingivitis as a manifestation of chronic mucocutaneous disease. J Dtsch Dermatol Ges. 2011;9(3):184-8. doi: 10.1111/j.1610-0387.2010.07543.x. [PubMed: 21050381].
  • 13. Mortazavi H, Abbasi F, Koopaie M, Esmaeili N. ELISA sensitivity in detection of autoantibodies desmoglein 1 and 3 in saliva and serum of patient with pemphigus vulgaris. Dermatol Cosmetic. 2014;5(2):69-75.
  • 14. Bhatia P, Dudhia B, Patel PS, Patel M. Benign mucous membrane pemphigoid. J Ahmedabad Dent Coll Hosp. 2011;2(48-54).
  • 15. Mignogna MD, Fortuna G, Leuci S, Ruoppo E, Marasca F, Matarasso S. Nikolsky's sign on the gingival mucosa: a clinical tool for oral health practitioners. J Periodontol. 2008;79(12):2241-6. doi: 10.1902/jop.2008.080217. [PubMed: 19053912].
  • 16. Orrico SR, Navarro CM, Rosa FP, Reis FA, Salgado DS, Onofre MA. Periodontal treatment of benign mucous membrane pemphigoid. Dent Today. 2010;29(7):100-2. quiz 102-3. [PubMed: 20687433].
  • 17. Barbosa Ldo N, Silva RS, Verardino GC, Gripp AC, Alves Mde F. Mucous membrane pemphigoid with severe esophageal stricture. An Bras Dermatol. 2011;86(3):565-8. [PubMed: 21738978].
  • 18. Abbayya K, Kadashetti V, Baad R, Lohana M. Desquamative gingivitis: A clinical sign in mucous membrane pemphigoid. European J Gen Dent. 2015;4(3):136-9. doi: 10.4103/2278-9626.163338.
  • 19. Laureano A, Cardoso J. Unilateral oral mucous membrane pemphigoid: refractory atypical presentation successfully treated with intravenous immunoglobulins. Case Rep Dermatol Med. 2015;2015:930859. doi: 10.1155/2015/930859. [PubMed: 25785208].
  • 20. Hasanoğlu Erbaşar GN. Localized oral mucous membrane pemphigoid: Successful treatment with intralesional triamcinolone acetonide injection. J Dent Oral Care. 2016;2(5):1-5. doi: 10.15436/2379-1705.16.1151.
  • 21. Dharman S, Muthukrishnan A. Oral mucous membrane pemphigoid - Two case reports with varied clinical presentation. J Indian Soc Periodontol. 2016;20(6):630-4. doi: 10.4103/jisp.jisp_155_16. [PubMed: 29238145].
  • 22. Capocasale G, Panzarella V, Rodolico V, Di Fede O, Campisi G. In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign. J Dermatol. 2018. doi: 10.1111/1346-8138.14267. [PubMed: 29479786].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments