The Effect of ?-TCP Particle Size on Mechanical and Setting Properties of Calcium Phosphate Bone Cements

AUTHORS

Mostafa Shahrezaei 1 , Jalal Shahrouzi 2 , * , Saeed Hesaraki 2 , Ali Zamanian 2

AUTHORS INFORMATION

1 Department of Orthopedic Surgery, AJA University of Medical Sciences, Tehran, IR Iran

2 Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, IR Iran

ARTICLE INFORMATION

Journal of Archives in Military Medicine: 2 (2); 16516
Published Online: May 17, 2014
Article Type: Research Article
Received: November 29, 2013
Accepted: May 2, 2014
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Abstract

Background: Calcium phosphate cements (CPCs) show several advantages over other materials, used for bone repair. For example, they are injectable, easily shapeable and remained localized. Therefore, they fill effectively bone defects with an irregular shape. Furthermore, CPCs are very bone compatible and also osteoconductive.

Objectives: This work aimed to investigate the effect of particle size on the mechanical and setting properties of ?-tricalcium phosphate (?-TCP) based cements. The rate of conversion of reactants to nano-hydroxyapatite (nHA) in the medium of human blood plasma is also studied.

Materials and Methods: In this study, we prepared CPCs consisting of ?-TCP (61%), dicalcium phosphate (DCP) (26%), calcium carbonate (CaCO3), hydroxyapatite (HA) (3%) as powder phase, in a solution of 3 wt% NaH2PO4 as liquid phase. In the next step, three different cements with the same formulation but different ?-TCP particle sizes (4 ?m, 10 ?m, 22 ?m) were prepared. Finally, we evaluated the setting time, compressive strength and the rate of conversion of reactants to apatite phase in blood plasma.

Results: Based on the results, the initial setting time decreased from 30 minutes for CPC with ?-TCP particle size of 22 ?m to 15 minutes for the cement with ?-TCP particle size of 4 ?m. Also, the cement prepared with the least ?-TCP particle size exhibited the maximum compressive strength after setting. The results revealed that reduction of ?-TCP particle size, the main component of the CPC, favors conversion of cement constituents to needle-like nano-apatite crystals when soaking in human blood plasma, and this leads to increment of mechanical strength.

Conclusions: In ?-TCP based CPCs, reduction of ?-TCP particle size favors the conversion of the cement constituents to nano-apatite crystals (when soaking in human blood plasma), which leads to reduction of setting time and increase in mechanical strength of CPCs.

Keywords

Bone Cements Hydroxyapatite Particle Size

© 2014, Journal of Archives in Military Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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